Medical Research

Conduct a literature review on [research question]:

Research question: [specific question]
Scope: [breadth and depth]
Purpose: [systematic review, background, etc.]
Timeframe: [years to include]
Databases: [PubMed, Cochrane, etc.]

Literature review plan:
- PICO(T) framework
- Search terms and Boolean operators
- Inclusion criteria
- Exclusion criteria
- Database search strategy
- Number of articles target
- Screening process (title, abstract, full-text)
- Quality assessment tool
- Data extraction form
- Synthesis approach
- Evidence grading
- Bias assessment
- Gap identification
- Citation management
- Writing structure

Design a research protocol for [study]:

Study type: [observational, interventional, etc.]
Research question: [hypothesis]
Population: [target participants]
Intervention: [if applicable]
Outcome: [primary endpoint]
Funding status: [available resources]

Protocol sections:
- Background and rationale
- Study objectives (primary and secondary)
- Study design and methodology
- Population (inclusion/exclusion criteria)
- Sample size calculation
- Intervention details (if applicable)
- Outcome measures and definitions
- Data collection procedures
- Statistical analysis plan
- Safety monitoring
- Ethical considerations
- Timeline and milestones
- Budget and resources
- Study organization
- Data management plan

Outline a grant proposal for [research project]:

Project: [title and focus]
Funding agency: [source]
Amount requested: [budget]
Duration: [timeline]
Preliminary data: [what you have]
Significance: [why it matters]

Grant proposal structure:
- Specific aims (hypothesis-driven)
- Significance and innovation
- Background and rationale
- Preliminary studies/data
- Research design and methods
- Expected outcomes
- Potential problems and alternatives
- Timeline and milestones
- Budget and justification
- Facilities and resources
- Team qualifications
- Dissemination plan
- References
- Biosketches
- Letters of support

Develop methodology for [research question]:

Research question: [question]
Study type: [quantitative, qualitative, mixed]
Population: [participants]
Setting: [where study occurs]
Feasibility: [practical constraints]

Methodology design:
- Study design selection and rationale
- Sampling strategy
- Sample size and power
- Recruitment procedures
- Data collection methods
- Instruments and measures (validity, reliability)
- Variables and operational definitions
- Confounders and how addressed
- Data analysis plan
- Quality control procedures
- Limitations acknowledged
- Ethical considerations
- IRB requirements
- Feasibility assessment

Interpret these study results:

Study: [description]
Results: [summarize findings]
Statistical significance: [p-values, CIs]
Effect size: [magnitude]
Study limitations: [known issues]
Comparison: [prior studies]

Interpretation framework:
- Primary outcome results
- Statistical vs clinical significance
- Effect size interpretation
- Confidence intervals meaning
- Secondary outcomes
- Subgroup analyses
- Consistency with hypothesis
- Biological plausibility
- Comparison to prior studies
- Strengths of study
- Limitations and biases
- Alternative explanations
- Clinical implications
- Research implications
- Generalizability

Write an abstract for [research paper]:

Study: [title]
Journal target: [publication]
Word limit: [count]
Study type: [design]
Key findings: [main results]
Implications: [so what]

Abstract structure:
- Background (1-2 sentences - why study matters)
- Objective (1 sentence - specific aim)
- Methods (2-3 sentences - design, population, intervention, outcomes)
- Results (3-4 sentences - primary and key secondary findings with numbers)
- Conclusions (1-2 sentences - interpretation and implications)
- Keywords (if required)
- Structured vs unstructured per journal
- No abbreviations (or define)
- No references
- Compelling and clear
- Numbers and statistics included

Organize citations for [manuscript/project]:

Project: [type of document]
Citation style: [AMA, APA, Vancouver, etc.]
Number of references: [approx count]
Sources: [journal articles, books, etc.]
Reference manager: [Zotero, Mendeley, EndNote]

Citation management:
- Reference manager setup
- Library organization strategy
- Tagging and folder system
- Citation while you write integration
- In-text citation format
- Reference list formatting
- Duplicate detection and removal
- Missing information completion
- URL and DOI verification
- Attachment management
- Sharing with collaborators
- Backup strategy
- Style switching
- Quality check process

Prepare IRB submission for [study]:

Study: [title and description]
Risk level: [minimal, more than minimal]
Vulnerable populations: [if any]
Data collection: [methods]
Informed consent: [process]
Institution: [IRB requirements]

IRB submission:
- Protocol summary
- Risk-benefit analysis
- Informed consent document
- Recruitment materials
- Data collection instruments
- Privacy and confidentiality measures
- Data security plan
- Vulnerable population protections
- Investigator qualifications
- Conflict of interest disclosure
- Site approval letters
- Funding source disclosure
- Regulatory approvals (IND, IDE if needed)
- Adverse event reporting plan
- Study closure plan